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Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics

J. S. Najem, G. J. Taylor, R. J. Weiss, M. S. Hasan, G. Rose, C. D. Schuman, A. Belianinov, C. P. Collier and S. A. Sarles

March, 2018

ACS Nano

https://pubs.acs.org/doi/10.1021/acsnano.8b01282

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Abstract

Solid-state neuromorphic systems based on transistors or memristors have yet to achieve the interconnectivity, performance, and energy efficiency of the brain due to excessive noise, undesirable material properties, and nonbiological switching mechanisms. Here we demonstrate that an alamethicin-doped, synthetic biomembrane exhibits memristive behavior, emulates key synaptic functions including paired-pulse facilitation and depression, and enables learning and computing. Unlike state-of-the-art devices, our two-terminal, biomolecular memristor features similar structure (biomembrane), switching mechanism (ion channels), and ionic transport modality as biological synapses while operating at considerably lower power. The reversible and volatile voltage-driven insertion of alamethicin peptides into an insulating lipid bilayer creates conductive pathways that exhibit pinched current–voltage hysteresis at potentials above their insertion threshold. Moreover, the synapse-like dynamic properties of the biomolecular memristor allow for simplified learning circuit implementations. Low-power memristive devices based on stimuli-responsive biomolecules represent a major advance toward implementation of full synaptic functionality in neuromorphic hardware.

Citation Information

Text


author          J. S. Najem and G. J. Taylor and R. J. Weiss and M. S. Hasan and 
                G. Rose and C. D. Schuman and A. Belianinov and C. P. Collier and S. A. Sarles
title           Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics
journal         ACS Nano
volume          12
number          5
pages           4702-4711
publisher       American Chemical Society
doi             10.1021/acsnano.8b01282
month           March
year            2018

Bibtex


@ARTICLE{ntw:18:mic,
    author = "J. S. Najem and G. J. Taylor and R. J. Weiss and M. S. Hasan and
            G. Rose and C. D. Schuman and A. Belianinov and C. P. Collier and S. A. Sarles",
    title = "Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics",
    journal = "ACS Nano",
    volume = "12",
    number = "5",
    pages = "4702-4711",
    publisher = "American Chemical Society",
    doi = "10.1021/acsnano.8b01282",
    month = "March",
    year = "2018",
    url = "https://pubs.acs.org/doi/10.1021/acsnano.8b01282"
}